{"id":67,"date":"2023-01-05T08:50:22","date_gmt":"2023-01-05T08:50:22","guid":{"rendered":"https:\/\/sciences.kmics.ac.in\/?p=67"},"modified":"2023-12-06T19:28:02","modified_gmt":"2023-12-06T19:28:02","slug":"food-restriction-may-not-reduce-leptin-gene-expression-in-obesity-condition-a-study-with-reference-to-an-animal-model-of-obesity-wnin-ob","status":"publish","type":"post","link":"https:\/\/sciences.kmics.ac.in\/index.php\/2023\/01\/05\/food-restriction-may-not-reduce-leptin-gene-expression-in-obesity-condition-a-study-with-reference-to-an-animal-model-of-obesity-wnin-ob\/","title":{"rendered":"Food restriction may not reduce leptin gene expression in obesity condition \u2013 A study with reference to an animal model of obesity, WNIN\/Ob"},"content":{"rendered":"\n<p><strong>Objective: <\/strong>Leptin an adipokine, deregulated in many cases of obesity is poorly understood under nutrition interventional strategies like food restriction.&nbsp; The present study addresses the above with the help of a rodent animal model of obesity, WNIN\/Ob<\/p>\n\n\n\n<p><strong>Methods: <\/strong>Male rats of WNIN\/Ob aged 35 days were allotted to three groups (n=4): (1) Rats with lean phenotype and fed <em>ad libitum<\/em>, (2) Rats with obesity phenotype and fed <em>ad libitum<\/em>, and (3) Rats with obesity phenotype and subjected to 60% food restriction. &nbsp;Rats were fed up to 90 days age, after which they were assessed for body weights, fat percentages and leptin.<\/p>\n\n\n\n<p><strong>Results: <\/strong>The higher body weights and fat percentages, in rats with obesity phenotype were reversed by food restriction to that of lean phenotype. Circulating leptin levels though showed a significant reduction (1.7 fold), they were significantly high (43 fold) compared to lean phenotype.&nbsp; The relatively high leptin gene expression in food restricted versus <em>ad libitum<\/em> fed ones (11 fold versus 4 fold with respect to lean) explains the higher circulating leptin levels.<\/p>\n\n\n\n<p><strong>Conclusions: <\/strong>Results suggest that mere food restriction may not reduce leptin gene expression and hence may not be a safer practice to reduce obesity.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"http:\/\/sciences.kmics.ac.in\/index.php\/kiran-kumar-battula-et-al-jan-05-2023\/\" style=\"background-color:#357e70\">Read Full Text<\/a><\/div>\n<\/div>\n\n\n\n<p><strong>Authors &amp; Affiliation<\/strong><\/p>\n\n\n\n<p>Kiran Kumar Battula<sup>1,2<\/sup>, Dinesh D.M Yadav<sup>2<\/sup>, Naga Muralidhar Merugu<sup>2<\/sup>, Prasad SMVK<sup>2<\/sup>, Chiranjeevi P V<sup>2<\/sup>, Rajender Rao Kalashikam<sup>2<\/sup>, Giridharan Nappanveettil*<sup>2,3<\/sup><\/p>\n\n\n\n<p><sup>1<\/sup>Keshav Memorial Institute of Commerce and Sciences, Hyderabad \u2013 500029<\/p>\n\n\n\n<p><sup>2<\/sup>National Institute of Nutrition, Hyderabad-500007<\/p>\n\n\n\n<p><sup>3<\/sup>Amrita Institute of Health Sciences, Kochi, Kerala<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective: Leptin an adipokine, deregulated in many cases of obesity is poorly understood under nutrition interventional strategies like food restriction.&nbsp; The present study addresses the above with the help of a rodent animal model of obesity, WNIN\/Ob Methods: Male rats of WNIN\/Ob aged 35 days were allotted to three groups (n=4): (1) Rats with lean [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-67","post","type-post","status-publish","format-standard","hentry","category-obesity-research"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":3,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts\/67\/revisions"}],"predecessor-version":[{"id":100,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts\/67\/revisions\/100"}],"wp:attachment":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/media?parent=67"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/categories?post=67"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/tags?post=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}