{"id":63,"date":"2023-01-05T08:35:01","date_gmt":"2023-01-05T08:35:01","guid":{"rendered":"https:\/\/sciences.kmics.ac.in\/?p=63"},"modified":"2023-12-14T16:58:11","modified_gmt":"2023-12-14T16:58:11","slug":"malat-1-may-interact-with-several-tumor-suppressor-and-dna-repair-genes-and-result-in-cancer","status":"publish","type":"post","link":"https:\/\/sciences.kmics.ac.in\/index.php\/2023\/01\/05\/malat-1-may-interact-with-several-tumor-suppressor-and-dna-repair-genes-and-result-in-cancer\/","title":{"rendered":"Malat-1 may interact with several tumor suppressor and DNA repair genes and result in cancer"},"content":{"rendered":"\n<p>Malat-1 is a long non-coding RNA (lncRNA) over-expressed in several types of cancers. In a large number of studies, its interaction was shown with several micro-RNAs, the degradation of which results in the de-repression of the genes causing cancers.&nbsp; As lncRNAs are known to regulate gene expression by diverse mechanisms, here in the present study we addressed by <em>insilico<\/em> methods of whether Malat-1 lncRNA has any interaction to sponge away the mRNA of genes, whose repression may lead to cancers.&nbsp; Through these studies, we predicted that Malat-1 lncRNA could interact with the mRNA of several tumor suppressor genes and genes of DNA repair mechanisms. Further <em>in vitro\/in vivo<\/em> studies can lead to a better understanding of these mechanisms and hence on therapeutic aspects.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"http:\/\/sciences.kmics.ac.in\/index.php\/divya-khatri-et-al-jan-5-2023\/\" style=\"background-color:#357e70\">Read Full Text<\/a><\/div>\n<\/div>\n\n\n\n<p>Authors: Divya Khatri and Kiran Kumar Battula<\/p>\n\n\n\n<p>Affiliation: Keshav Memorial Institute of Commerce and Sciences, Hyderabad \u2013 500029<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Malat-1 is a long non-coding RNA (lncRNA) over-expressed in several types of cancers. In a large number of studies, its interaction was shown with several micro-RNAs, the degradation of which results in the de-repression of the genes causing cancers.&nbsp; As lncRNAs are known to regulate gene expression by diverse mechanisms, here in the present study [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-63","post","type-post","status-publish","format-standard","hentry","category-cancer-research"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts\/63","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/comments?post=63"}],"version-history":[{"count":4,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts\/63\/revisions"}],"predecessor-version":[{"id":113,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/posts\/63\/revisions\/113"}],"wp:attachment":[{"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/media?parent=63"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/categories?post=63"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sciences.kmics.ac.in\/index.php\/wp-json\/wp\/v2\/tags?post=63"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}